Symbol
Name
ID

Cog6
component of oligomeric golgi complex 6
MGI:1914792

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Decreased specific anti-polysaccharide antibody level	Impaired T cell function	Splenomegaly	Inflammation of the large intestine	Recurrent infections
Disease(s) Associated with COG6
congenital disorder of glycosylation type IIl

Mouse Phenotypes

decreased transitional stage T2 B cell number

increased eosinophil cell number

increased granulocyte number

decreased marginal zone B cell number

increased B-2 B cell number

increased follicular B cell number

increased plasma cell number

increased KLRG1-positive NK cell number

decreased Ly6C-positive immature NK cell number

decreased Ly6C-positive mature NK cell number

decreased memory-marker NK cell number

increased memory-marker NK cell number

decreased NK cell number

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, alpha-beta memory T cell number

increased KLRG1+ CD4 alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

decreased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

increased KLRG1+ CD8 alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased memory-marker CD4-negative NK T cell number

increased CD4-negative NK T cell number

decreased memory-marker CD4-positive NK T cell number

decreased CD4-positive NK T cell number

decreased NK T cell number

decreased alpha-beta T cell number

increased KLRG1-positive T-helper cell number

increased effector memory T-helper cell number

decreased T-helper cell number

increased CD5-positive gamma-delta T cell number

decreased memory-marker gamma-delta T cell number

increased memory-marker gamma-delta T cell number

increased gamma-delta T cell number

decreased T cell number

increased Ly6C high monocyte number

increased monocyte cell number

increased leukocyte cell number

increased anti-nuclear antigen antibody level

Availability

Mouse Genotype

Cog6^{tm1a(EUCOMM)Wtsi}/Cog6^{tm1a(EUCOMM)Wtsi}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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